New technologies encompass revolutionary possibilities for achieving the Sustainable Development Goals (SDGs) and the priorities of European Green Deal, fostering productivity and innovation, creating new employment opportunities, improving drastically workplace safety and reducing the environmental footprint of the industrial sector and other economic activities. The numerous applications and possibilities of the 4IR can also contribute decisively to the promotion of energy democracy and low-carbon systems ensuring affordable and clean energy. Furthermore, the analysis of large-scale interconnected databases can support the adaptation of economic and social systems to climate change and contribute to the protection of the environment and biodiversity. In the same way, the development of smart farming and agriculture data in real time can optimise farm management and food supply chains. Similar possibilities exist regarding the improvement of quality of life and sustainability of cities and communities such as connected and automated mobility for reducing traffic accidents and improving the environmental footprint and efficiency of transportation systems. Innovative application in telemedicine, remote care and robotics can improve the accessibility, affordability, quality and efficiency of health services, contribute to the prevention of non-communicable diseases, and support independent living while protecting medical staff. Last but not least, digitization is expected to drastically boost the improvement of public services and administration in terms of effectiveness, quality, transparency and accessibility. The possibilities of the 4IR seem endless.